Hantuchova won 6-1, 6-3, in a 73-minute match, breaking Wozniacki’s serve five times. Hantuchova hit 26 winners, Wozniacki eight.
With Kim Clijsters’s loss Thursday, the Wozniacki upset means that, for the first time in the Open era, the top two seeded women’s players have failed to make the round of 16 at a Grand Slam event.
Wozniacki won the clay-court warmup event, the Brussels Open, with her left thigh bandaged. She played the first two rounds at Roland Garros with the same thigh wrapped, but had nothing on her leg today.
In other women’s results, last year’s French champion, Francesca Schiavone, advanced and Sam Stosur, the runnerup last year, lost.
On the men’s side, Roger Federer continued to roll, beating No. 29 Jank Tipsarevi, 6-1, 6-4, 6-3. Later today, Novak Djokovic, who hasn’t lost since November, will play the 2009 U.S. Open champion Juan Martin Del Potro.
French Open: Schedule, results