Bradley Beal is the only Wizards player with a role in All-Star Weekend.
The Pistons beat the Wizards by a combined 41 points in their first two meetings but Lawrence Frank said Washington is much different with John Wall.
Bradley Beal had a career-high 28 points off the bench on Monday in Milwaukee but will stay in a reserve role against Detroit.
Nene recorded his third consecutive double-double and made several huge plays in the clutch in win over the Bucks.
The Wizards are riding a three-game winning streak and Coach Randy Wittman doesn't want to disrupt anything. So Bradley Beal will come off the bench as he continues to recover from a sprained wrist.
Though the team has surged in recent weeks at home, Washington's road record remains wretched.
The Wizards swept their last home stand before the all-star game and defeated the Los Angeles Clippers, New York and Brooklyn by a combined 33 points.
The Lakers had to go after Dwight Howard when he pouted his way out of Orlando, but his pairing with Kobe Bryant has failed because of clashing personalities and agendas.
Bradley Beal is expected to come back after a five-game absence and help the Wizards get revenge for a double-overtime loss to Brooklyn.
"I think I'm going to play tomorrow," the rookie says after shaking off wrist injury.