It took 27 games, but the Wizards finally played with their projected starting lineup on Christmas.
Seraphin scored 16 points in a season-high 28 minutes.
Big man has come off the bench since returning from plantar fasciitis in his right foot.
With Nene back, the Wizards seek to beat the Magic for the third time this season.
The big man missed Monday's win over the Celtics with a sore right knee.
Nene had just returned Friday after missing five straight games with right plantar fasciitis.
The Wizards seek to avenge Sunday's embarrassing loss to the Celtics.
The big man had eight points and eight rebounds in 18 minutes off the bench.
Nene is expected to return after missing five games with right plantar fasciitis.
The big man has missed the Wizards' last five games with right plantar fasciitis.