The Wizards managed to beat the Pelicans Saturday despite scoring a season-low 83 points.
The Wizards are looking to avoid a three-game winning streak.
Neither player is expected to miss significant time.
Coach Randy Wittman suggested his team would've lost the game in years' past.
Porter (hamstring) was inactive Saturday against the Bucks and Nene (foot) played just six minutes.
The Wizards are in Milwaukee to complete a back-to-back.
Seraphin scored 12 points in the second quarter and blocked three shots.
The Wizards host the Cavaliers on national television.
The Wizards host the Mavericks with Bradley Beal back from injury
The shooting guard has been out since Oct. 10 with a fractured left wrist.