The big man had eight points and eight rebounds in 18 minutes off the bench.
The big man has missed the Wizards' last five games with right plantar fasciitis.
Pierce was taken out at the end of the third quarter.
The Wizards host Kobe Bryant and the Lakers for the first and last time this season.
The power forward has missed the Wizards' last four games.
Nene has missed the Wizards' last three games with right plantar fasciitis.
The Wizards managed to beat the Pelicans Saturday despite scoring a season-low 83 points.
The Wizards are looking to avoid a three-game winning streak.
Neither player is expected to miss significant time.
Coach Randy Wittman suggested his team would've lost the game in years' past.