Elsewhere in Kabul, police seized control of ballot boxes from September's disputed parliamentary elections, the latest escalation of the government's attempt to prosecute alleged voting fraud.
The bomb blast echoed across Kabul but caused relatively little damage to the multistory glass tower, which in addition to the hotel houses apparel, electronics and jewelry shops.
The tower's new entrance, rebuilt after a bombing last year, was a mangle of twisted metal, but its upper-story windows remained intact. Carrots and apples from an adjacent juice shop were strewn on the ground, along with shards from the plate-glass window of a bakery. The severed head of the suicide bomber lay on the muddy sidewalk, under scraps of metal sheeting.
Less than a month ago, insurgents attacked Kabul's Finest supermarket, which is not far from many embassies and was popular with foreigners. The two blasts, as well as other recent attacks in Kabul, have heightened fear among residents that the relative calm that existed last year in the Afghan capital is being overtaken by violence.
For about two hours after the bombing, Afghan police officers and soldiers ran back and forth in front of the hotel, acting on rumors - which proved to be unfounded - that other would-be suicide bombers had escaped into the mall and were hiding on the upper floors.
There were periodic bursts of gunfire, but the target of the shots was unclear.
The Safi Landmark complex suffered worse damage last year when suicide bombers targeted Indian civilians living in a guesthouse nearby. After that blast, Hassan Razaei spent $30,000 to rebuild his bakery. On Monday, the facade of his store was destroyed again.
"I don't have a choice but to rebuild my shop," Razaei said. "The problem is nobody will come to my shop for another month. We were relying on the customers of Safi Landmark. They were shopping there and buying their cookies here."
At the headquarters of the Independent Election Commission in Kabul, police took control of the data center and ballot warehouse on Monday, presumably to help a special court investigate alleged voting fraud during the parliamentary elections.
The work of the special court has been controversial because many consider it an attempt by the government to manipulate the results and install more loyalists of President Hamid Karzai.
Karzai attempted to delay seating the parliament until the investigations were completed. The elected members and Western diplomats objected, leading to a compromise in which parliament was inaugurated Jan. 26.
The commission's chief electoral officer, Abdullah Ahmadzai, said it would cooperate with the special court but would not participate in any recount.
"For us, the case of the 2010 election ended with the inauguration of the National Assembly," Ahmadzai said.
Special correspondents Habib Zahori and Javed Hamdard contributed to this report.