"Mitt and I are always very, very partial to Paul Ryan," she said, but "we don't even know if he's going to run."
After her speech, she greets her sons.
"I think it's a huge sacrifice and I think it is very hurtful many times for the spouse to have to watch the kind of abuse that you know you have to go through," Ann Romney told CNN.
No one was injured.
On Friday, a plane carrying Ann Romney was forced to make an emergency landing in Denver, Colo., when pilots noticed smoke in the cockpit.
Mitt and Ann Romney will grant their first interview since the 2012 election to Fox News.
Ann Romney, wife of Republican presidential candidate Mitt Romney, spoke at the Republican National Convention on Tuesday night.
The magazine reports that ABC is in talks with First Lady Michelle Obama to host as well.