Pryor was born in January 1963 to Barbara and David Pryor in Fayetteville, Ark. Three years later, his father was elected to the U. S. House. David Pryor had a long political career that included a stint as Arkansas' governor (from 1974 to 1976) and U.S. Senator (from 1979 to 1997). Like his father, Mark Pryor attended the University of Arkansas, where he received a B.A. in history and a J.D.
After graduating from law school Pryor took a job with the Wright, Lindsey and Jennings law firm in Little Rock. Two years later, in 1990, Pryor was elected to the State House of Representatives representing sections of Little Rock. He won reelection in 1992 and in 1994 ran for state attorney general. Pryor lost in the Democratic primary to incumbent Winston Bryant (D-Ark.). Pryor then returned to private law practice.
In 1995 he was diagnosed with clear-cell sarcoma, a rare form of cancer. He underwent tendon transplant surgery in his heel and the cancer has not returned.
After nearly a year of recovery, Pryor launched another attempt to become Arkansas' attorney general and in 1998 he succeeded and became the youngest attorney general in the nation. In that role, he pushed to increase penalties on nursing homes accused of neglect and abuse and to strengthen background checks of long-term health care employees. He was successful in setting up a state "do not call" list but failed to get legislation passed for another of his priorities - a hate-crime law.
In 2001 Pryor announced that he would challenge U.S. Sen. Tim Hutchinson (R-Ark.), who had taken that seat in 1996 when David Pryor retired. Hutchinson was a strong conservative, a Baptist minister and the founder of a Christian school. Though the incumbent's Christian credentials and conservative voting record would have seemingly made him a favorite for reelection, he was harmed by personal problems. Specifically, he divorced his wife of 29 years in August 2000 and married a former member of his House staff less than a year later. The divorce and remarriage disturbed some of his supporters who thought it reflected poorly on his character.
Pryor did not mention that part of Hutchinson's personal history during the campaign. He ran on a relatively conservative platform that included support for the Second Amendment, increased military spending and the Iraq war. He also changed his stance on abortion from pro-choice in 1998, to opposing abortion except in cases of rape, incest or where continuation of the pregnancy would threaten the life and health of the mother.
Despite campaign visits by President Bush to Arkansas, Hutchinson fell behind in polls during the middle of the year. Pryor played up his Christianity in his advertising and won the election with 54 percent of the vote. He was the only Democrat to defeat an incumbent Republican in 2002, a year that saw the GOP gain in both the House and Senate.
In his first term in the Senate, Pryor joined Democrats in opposing drilling in the Arctic National Wildlife Refuge but broke with his party to support a ban on partial-birth abortion. He also opposed both President Bush's surge plan to send more troops to Iraq and the Democratic plan setting a public timetable for withdrawing troops from Iraq. (He supported a secret timetable.)
In 2004, Pryor endorsed Sen. John F. Kerry (D-Mass.) for president and encouraged him to come to Arkansas and hunt. It was another example of Pryor encouraging Democrats to show the South that they're not all elitist wine drinkers. Of Kerry, he said, "[we] have a little different approach on some issues. But I'm comfortable with him as a person and a leader."
In 2008 Pryor ran for reelection with no Republican challenger. Some Republicans hoped former Gov. Mike Huckabee (R-Ark.), who had dropped out of the presidential race a week before the Senate filing deadline, would enter the race, but he did not.
Pryor won re-election in 2008, defeating Green Party candidate Rebekah Kennedy. Pryor received 79 percent of the vote and Kennedy got 21 percent.
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