The main concern is your "sleeping altitude," the height at which you spend the night. If you are planning to slumber at 10,000 feet, it's wise to acclimate by overnighting at a midway point the night before. Also, if you are quickly ascending from low to high altitudes and then partaking in rigorous activities, you might want to talk to a doctor about Diamox, a preventative medication. However, Bezruchka cautions that you might feel sicker from the prescription than the rise in elevation.
If you do start to experience shortness of breath, increased heartbeat, nausea or headache (like a slight hangover), you could try gingko biloba, though it is not FDA-approved. Otherwise, unless you have a medical condition (if so, check with a doctor before you go), upping your carbs, drinking more fluids and taking it easy are the best cure.
We have a 12-hour layover in Frankfurt. Any advice on sights near the train station from the airport?
The train ride from Frankfurt's airport to the main downtown station, Hauptbahnhof, takes about 45 minutes one way; subtracting the commute and an hour-plus for flight check-in and security should leave you with enough time for a whirlwind tour of culture, local cuisine, shopping and apple wine.
From the train station, walk toward the Main River and to the Museum Embankment (Museumsufer), 15 to 20 minutes by foot. The promenade, akin to Manhattan's Museum Mile, has 13 cultural institutions, nine on the south side alone. Highlights include the Museum of Modern Art, the German Architecture Museum, the German Cinema Museum and the Staedel Art Institute and Municipal Gallery, which also houses the well-regarded Holbein's restaurant. Cross the Holbeinsteg footbridge for an expansive river view of the city skyline, then return to the south bank and head to the Sachsenhausen quarter. Wander around the neighborhood's narrow alleys, lined with old taverns, smart boutiques and pubs that pour the local tipple: apple wine. Quaff a glass before you take flight again: The ancient brew is known to stimulate blood circulation -- a bonus for fliers.
For more info: German National Tourist Board, 800-651-7010, www.cometogermany.com; for Frankfurt's tourism office, www.frankfurt-tourismus.de.
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