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Birth of Child Called First From Frozen Ovarian Tissue

By Rick Weiss
Washington Post Staff Writer
Friday, September 24, 2004; Page A01

A Belgian woman who had pieces of her ovaries surgically removed and frozen seven years ago, before cancer chemotherapy left her sterilized, gave birth yesterday to a healthy baby after doctors transplanted the ovarian tissue back into her abdomen, researchers reported.

The birth -- the first from frozen ovarian tissue, her doctors said -- suggests that many of the thousands of girls and women who each year are made infertile by cancer treatments may soon be able to preserve the option of having children later.

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If the procedure proves safe, doctors said, it could even become an attractive possibility for women who are healthy but want to delay childbearing a decade or two.

Immature eggs, which lay nestled in girls' ovaries from birth, age throughout life but are not thought to age while frozen. And because the major impediment to fertility in older women is the age of the eggs, rather than the womb, women in their forties, fifties or older may be able to become pregnant by having preserved ovarian tissue reimplanted after decades in the freezer.

"It's quite exceptional," said Wulf Utian, a gynecologist and executive director of the North American Menopause Society in suburban Cleveland. "This woman has essentially been restored to a normal reproductive state after having been made temporarily menopausal by chemotherapy."

Utian and others warned that despite evidence to the contrary, there remains a small chance that one of the woman's chemotherapy-damaged ovaries may have recovered sufficiently to have given rise to the pregnancy.

That lingering doubt -- along with many uncertainties about the procedure's safety for women and for their babies -- mean the technique should still be considered experimental, experts said.

Several previous efforts to achieve pregnancy from thawed ovarian tissue failed -- in some cases, probably because of an inadequate blood supply after being put back in the body.

In some cases, the bits of tissue, each of which can contain hundreds of immature eggs, have been transplanted to novel locations -- including, in at least one case, under the skin of a woman's forearm. That approach made it easy to tell when the woman was ovulating -- a tiny bump would appear under her skin -- and the egg could be removed with a needle for fertilization in a lab dish with her husband's sperm.

The events leading to yesterday's delivery of an eight-pound girl to a 32-year-old Belgian cancer survivor began seven years ago when the woman -- who was identified by news services as Ouarda Touirat -- had Hodgkin's lymphoma diagnosed. The treatment usually destroys the ovaries' reproductive potential.

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