Gum Disease, Pancreatic Cancer Link Seen

By Kathleen Doheny
HealthDay Reporter
Tuesday, January 16, 2007; 12:00 AM

TUESDAY, Jan. 16 (HealthDay News) -- Having periodontal or gum disease may boost the risk of getting pancreatic cancer, according to new research from Harvard Medical School involving more than 51,000 men.

"Men who had reported periodontal disease had a 64 percent higher risk of pancreatic cancer [or were 1.6 times more likely to get it] compared to those who didn't have periodontal disease," said the study's lead author, Dominique S. Michaud.

The study provides the first strong evidence that gum disease may increase pancreatic cancer risk, added Michaud, an assistant professor of epidemiology at the Harvard School of Public Health in Boston.

Her team published the findings in the Jan. 17 issue of theJournal of the National Cancer Institute.

Two previous studies have uncovered a link between tooth loss or gum inflammation and pancreatic cancer, Michaud said. But one included all smokers and the other did not control for smoking, known to boost the risk of pancreatic cancer, in the analysis.

The pancreas, a gland behind the stomach, makes pancreatic juice, which helps break down fats and proteins in foods. The gland also produces the hormone insulin, which helps regulate blood sugar.

In their 16-year study, Michaud and her colleagues followed 51,529 men who participated in the Health Professional Follow-Up Study, which began in 1986. The researchers controlled for the effects of smoking.

"Our study was a prospective study of health professionals," Michaud said. "Not MDs, but dentists, podiatrists, veterinarians."

They also calculated the risk of pancreatic cancer among smokers and nonsmokers.

"Among men who never smoked, having periodontal disease led to them being twice as likely to get pancreatic cancer," Michaud said. That helped convince the researchers that periodontal disease and pancreatic cancer were linked.

The mechanism behind the link isn't known, Michaud said. And while her team found an association, it is not a proven cause-and-effect relationship.

One possible explanation is that inflammation from gum disease may somehow promote pancreatic cancer.

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