Chemicals May Play Role in Rise in Obesity

By Elizabeth Grossman
Special to The Washington Post
Monday, March 12, 2007

Too many calories and too little exercise are undeniably the major factors contributing to the obesity epidemic, but several recent animal studies suggest that environmental exposure to widely used chemicals may also help make people fat.

The evidence is preliminary, but a number of researchers are pursuing indications that the chemicals, which have been shown to cause abnormal changes in animals' sexual development, can also trigger fat-cell activity -- a process scientists call adipogenesis.

The chemicals under scrutiny are used in products from marine paints and pesticides to food and beverage containers. A study by the Centers for Disease Control and Prevention found one chemical, bisphenol A, in 95 percent of the people tested, at levels at or above those that affected development in animals.

These findings were presented at last month's annual meeting of the American Association for the Advancement of Science. A spokesman for the chemical industry later dismissed the concerns, but Jerry Heindel, a top official of the National Institute of Environmental Health Sciences (NIEHS), who chaired the AAAS session, said the suspected link between obesity and exposure to "endocrine disrupters," as the chemicals are called because of their hormone-like effects, is "plausible and possible."

Bruce Blumberg, a developmental and cell biologist at the University of California at Irvine, one of those presenting research at the meeting, called them "obesogens" -- chemicals that promote obesity.

Obesity has become a major health concern as people in the United States and around the world have become increasingly overweight, raising their risk of cardiovascular diseases, diabetes, stroke and certain cancers. The World Health Organization estimates that more than a billion adults worldwide are overweight and 300 million are obese. Scientists have begun examining a wide range of possible causes beyond eating too much and exercising too little -- including possible chemical exposures.

Blumberg began to suspect a link while trying to pinpoint how one endocrine disrupter, tributyltin, affects genetic mechanisms in the reproductive system. Tributyltin is used as a marine and agricultural fungicide, an antimicrobial agent in industrial water systems, and in plastics; it can cause serious sexual abnormalities in marine animals.

"What we discovered," Blumberg said, is that tributyltin disrupted genetic interactions that regulate fat-cell activity in animals. "Exposure to tributyltin is increasing the number of fat cells, so the individual will get fatter faster as these cells produce more of the hormones that say 'feed me,'" Blumberg said. The exposed animals, he added, remain predisposed to obesity for life.

Retha R. Newbold, a developmental biologist at the NIEHS, has seen similar lifetime effects in her work with diethylstilbestrol (DES), a potent synthetic estrogen she has studied for 30 years.

Newbold's research has shown that mice exposed to DES during early development produced more fat cells, larger fat cells, and more abdominal fat than those not exposed. Exposed mice became obese adults and remained obese even on reduced calorie and increased exercise regimes. Like tributyltin, DES appeared to permanently disrupt the hormonal mechanisms regulating body weight.

"Once these genetic changes happen in utero, they are irreversible and with the individual for life," Newbold said.

DES was widely prescribed for women during pregnancy from the 1940s until 1971, when it was withdrawn after being linked to cancer. Taken by perhaps 8 million women, DES has caused reproductive abnormalities in children and grandchildren of women who took it. Whether its effects include promoting obesity has yet to be determined, but its effects on animal metabolism -- it is also used to fatten livestock -- are similar to those caused by bisphenol A, a chemical most people now encounter daily.

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