Brain Studies Show ADHD Is Real Disease

By Steven Reinberg
HealthDay Reporter
Monday, August 6, 2007; 12:00 AM

MONDAY, Aug. 6 (HealthDay News) -- Attention-deficit/hyperactivity disorder (ADHD) is a real disease linked to changes in production of the brain chemical dopamine, two new reports suggest.

In the first report, researchers found that a variant of the dopamine receptor gene may help cause the behavioral condition but also improve its long-term outcome.

"If you have a certain variant of this gene, you have a greatly increased risk of having ADHD," said lead researcher Dr. Philip Shaw, a researcher in the Child Psychiatry Branch at the U.S. National Institute of Mental Health. However, "what we found that was surprising was that having this variant was also associated with having a better outcome from ADHD," he said.

"The kids who had the risk gene tended to get better," Shaw said. "They also tended to be a little bit more intelligent."

Not all children with ADHD have this particular gene variant, Shaw said. "About one-quarter to one-fifth of children with ADHD has this gene variant," he said. "That's higher than the general population where about a fifth to a sixth has the variant."

In a second study, scientists found that, in contrast to the common wisdom, ADHD is associated withlowereddopamine production.

Both reports were published in the August issue of theArchives of General Psychiatry.

In the first gene study, Shaw's team compared 105 children with ADHD with 103 healthy children. The youngsters averaged about 10 years of age.

The researchers looked at the children's MRI brain scans as well as their DNA. In addition, 67 of the children with ADHD were evaluated six years later.

Shaw's team found that a variant in the dopamine D4 receptor gene (DRD4) was associated with ADHD. This form of the gene is linked with thinner tissue in areas of the brain that control attention.

Among the children with ADHD seen over six years, those who had this gene variant had better outcomes and had regained healthy tissue thickness in the affected brain region. This may explain ADHD's natural history of improvement with age, the researchers noted.

Further research could help develop treatments that will help children recover from ADHD more quickly, Shaw said.

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