Children of Centenarians Face Lower Heart Risks

TUESDAY, Dec. 16 (HealthDay News) -- Longevity runs in families, the saying goes, and new research shows there may be genetic and physiological reasons for the phenomenon.

The children of people who live to 100 and beyond are themselves much less likely to develop cardiovascular diseases, such as heart disease and stroke, and even diabetes, researchers found.

But they aren't impervious to non-cardiovascular health problems, such as cancer, dementia and depression.

The findings stem from an analysis of health data collected over a decade by the New England Centenarian Study, which focuses on people aged 97 and older and their family members. It's the first study to track the health of children of centenarians as they age.

"This confirms what we were already suspecting, and definitely suggests that there is a genetic component to the ability to create exceptional longevity," said study author Emily R. Adams, a third-year medical student at Boston University School of Medicine.

Adams and her Boston University colleagues, Dr. Dellara F. Terry and Dr. Thomas Perls, director of the New England Centenarian Study, presented their findings in the November issue of the Journal of the American Geriatrics Society.

For the 10-year study, initial and follow-up questionnaires regarding health status were presented to 440 children of centenarians, as well as to 192 men and women whose parents had not lived past 100. The average age of the participants was 72 when the study began in 1997.

The researchers found that compared to the average adult, children of centenarians had a 78 percent lower risk for a heart attack, an 83 percent lower risk for a stroke, and an 86 percent lower risk for developing diabetes.

They were also 81 percent less likely to die during the course of the study.

The researchers said the findings generally reinforce the important role that genetics play in reaching extreme old age, and specifically highlight the cardiovascular leg up children of centenarians appear to inherit from their parents.

But, Adams added, while good genetic lineage may portend a longer life, it doesn't guarantee protection against all diseases.

"You might expect that centenarian offspring would do better as they age, and that is true. They do follow a different trajectory, and go down a less steep slope," she said.