Jose E. Serrano was elected to the New York State Assembly in 1974 and was re-elected to seven consecutive terms. He was elected to the U.S. House in a March 1990 special election with 93 percent of the vote over Simeon Golar.
He was re-elected to a full term in November 1990 with 93 percent of the vote, defeating Republican Joseph Chiavaro. He was re-elected in 1992 with 91 percent of the vote.
Serrano faced no Republican challenger in 1994. In 1996, he was re-elected with 96 percent of the vote against Republican Rodney Torres. He won re-election in 1998, defeating Republican Thomas Bayley with 95 percent of the vote. He defeated Republican Aaron Justice in 2000 with 95 percent of the vote.
He defeated Republican Frank Dellavalle in 2002 with 92 percent of the vote.