In 1992, Blanche Lincoln defeated then-U.S. Rep. Bill Alexander, a 24-year incumbent, in Arkansas' 1st District Democratic primary and easily defeated a Republican challenger in November. She won re-election in 1994, though by a closer-than-expected 54-46 percent margin over Jonesboro lawyer Warren Dupwe. She did not seek re-election in 1996, choosing instead to leave Congress and raise her infant twins.
Lincoln was elected to the U.S. Senate in 1998, defeating Republican state Sen. Fay Boozman with 55 percent of the vote.
In 2004, she faced a Democrat, political neophyte Lisa Burks of Hot Springs in the May primary.