| No. | Team | Player | Pos. | College |
|
| 1. | San Francisco 49ers
| Alex Smith | QB | Utah |
|
| 2. | Miami Dolphins | Ronnie Brown | RB | Auburn |
|
| 3. | Cleveland Browns
| Braylon Edwards
| WR
| Michigan
|
|
| 4. | Chicago Bears
| Cedric Benson | RB | Texas |
|
| 5. | Tampa Bay Buccaneers
| Carnell Williams
| RB
| Auburn
|
|
| 6. | Tennessee Titans | Adam Jones | CB | West Virginia |
|
| 7. | Minnesota Vikings
From Oakland
| Troy Williamson
| WR
| South Carolina
|
|
| 8. | Arizona Cardinals | Antrel Rolle | CB | Miami |
|
| 9. | Washington Redskins | Carlos Rogers
| CB
| Auburn
|
|
| 10. | Detroit Lions | Mike Williams | WR | USC |
|
| 11. | Dallas Cowboys | Demarcus Ware
| DE
| Troy
|
|
| 12. | San Diego Chargers
From New York Giants
| Shawne Merriman | DE/LB | Maryland |
|
| 13. | New Orleans Saints
From Houston Texans
| Jammal Brown
| RT
| Oklahoma
|
|
| 14. | Carolina Panthers | Thomas Davis | LB | Georgia |
|
| 15. | Kansas City Chiefs
| Derrick Johnson
| LB
| Texas
|
|
| 16. | Houston Texans
From New Orleans Saints
| Travis Johnson | DT | Florida State |
|
| 17. | Cincinnati Bengals | David Pollack
| DE
| Georgia
|
|
| 18. | Minnesota Vikings | Erasmus James | DE | Wisconsin |
|
| 19. | St. Louis Rams
| Alex Barron
| OT
| Florida State
|
|
| 20. | Dallas Cowboys
From Buffalo
| Marcus Spears | DE | LSU |
|
| 21. | Jacksonville Jaguars
| Matt Jones
| WR
| Arkansas
|
|
| 22. | Baltimore Ravens | Mark Clayton | WR | Oklahoma |
|
| 23. | Oakland Raiders
(From Seattle) | Fabian Washington
| CB
| Nebraska
|
|
| 24. | Green Bay Packers | Aaron Rodgers | QB | California |
|
| 25. | Washington Redskins
From Denver
| Jason Campbell
| QB
| Auburn
|
|
| 26. | Oakland
From Seattle
| Chris Spencer | OL | Mississippi |
|
| 27. | Atlanta Falcons
| Roddy White
| WR
| UAB
|
|
| 28. | San Diego Chargers | Luis Castillo | DT | Northwestern |
|
| 29. | Indianapolis Colts
| Marlin Jackson
| CB
| Michigan
|
|
| 30. | Pittsburgh Steelers | Heath Miller | TE | Virginia |
|
| 31. | Philadelphia Eagles
| Mike Patterson
| DT
| USC
|
|
| 32. | New England Patriots
| Logan Mankins | OL | Fresno State |
