| No. | Team | Player | Pos. | College |
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| 1. | Miami Dolphins | Jake Long | Offensive Tackle | Michigan |
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| 2. | St. Louis Rams | Chris Long | Defensive End | Virginia |
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| 3. | Atlanta Falcons | Matt Ryan | Quarterback | Boston College |
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| 4. | Raiders | Darren McFadden | Running Back | Arkansas |
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| 5. | Kansas City Chiefs | Glenn Dorsey | Defensive Tackle | LSU |
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| 6. | New York Jets | Vernon Gholston | Defensive End | Ohio State |
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| 7. | New Orleans Saints From New England, San Francisco | Sedrick Ellis | Defensive Tackle | USC |
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| 8. | Jacksonville Jaguars Baltimore | Derrick Harvey | Defensive End | Florida |
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| 9. | Cincinnati Bengals | Keith Rivers | Linebacker | USC |
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| 10. | New England Patriots From New Orleans | Jerod Mayo | Linebacker | Tennessee |
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| 11. | Buffalo Bills | Leodis McKelvin | Cornerback | Troy |
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| 12. | Denver Broncos | Ryan Clady | Offensive Tackle | Boise State |
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| 13. | Carolina Panthers | Jonathan Stewart | Running Back | Oregon |
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| 14. | Chicago Bears | Chris Williams | Offensive Tackle | Vanderbilt |
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| 15. | Kansas City Chiefs From Detroit Lions | Branden Albert | Offensive Lineman | Virginia |
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| 16. | Arizona Cardinals | Dominique Rodgers-Cromartie | Cornerback | Tennessee State |
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| 17. | Detroit Lions From Kansas City, Minnesota | Gosder Cherilus | Offensive Tackle | Boston College |
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| 18. | Baltimore Ravens From Houston | Joe Flacco | Quarterback | Delaware |
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| 19. | Carolina Panthers From Philadelphia | Jeff Otah | Offensive Lineman | Pittsburgh |
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| 20. | Tampa Bay Buccaneers | Aqib Talib | Cornerback | Kansas |
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| 21. | Atlanta Falcons From Washington | Sam Baker | Offensive Tackle | USC |
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| 22. | Dallas Cowboys From Cleveland | Felix Jones | Running Back | Arkansas |
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| 23. | Pittsburgh Steelers | Rashard Mendenhall | Running Back | Illinois |
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| 24. | Tennessee Titans | Chris Johnson | Running Back | East Carolina |
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| 25. | Dallas Cowboys From Seattle | Mike Jenkins | Cornerback | South Florida |
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| 26. | Houston Texans (From Baltimore, Jacksonville) | Duane Brown | Offensive Tackle | Virginia Tech |
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| 27. | San Diego Chargers | Antoine Cason | Defensive Back | Arizona |
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| 28. | Seattle Seahawks (From Dallas) | Lawrence Jackson | Defensive End | USC |
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| 29. | San Francisco 49ers From Indianapolis | Kentwan Balmer | Defensive Tackle | North Carolina |
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| 30. | New York Jets From Green Bay | Dustin Keller | Tight End | Purdue |
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| 31. | New York Giants | Kenny Phillips | Safety | Miami (Fl.) |
