MIAMI, SEPT. 17 -- Pan American Corp. is expected to announce Wednesday that it will lay off up to 10 percent of its work force because of the problems besetting the airline industry.

The across-the-board cuts will affect as many as 2,800 of the company's 28,000 employees nationwide, according to labor and management sources.

Bill Genoese, director of the airline division of the International Brotherhood of Teamsters, said: "Pan Am has plans to cut up to 10 percent due to the fuel crisis. The cuts will be across the board."

Jeffrey Kriendler, a Pan Am spokesman, said the company would have no comment.

Pan Am, like other airlines, has been badly hurt by the rising cost of jet fuel stemming from the Persian Gulf crisis.

A New York airline analyst said he expected the announcement to come when Pan Am Chairman Thomas Plaskett addresses stock analysts at a meeting Wednesday in New York.

Pan Am would not be the first airline to cut its staff in response to economic problems. Last month, USAir announced plans to cut 3,600 employees, or 7 percent of its work force, and reduced its 1991 growth projection from 6 percent to 2 percent.

But because of a long string of losses -- Pan Am lost nearly $2 billion in the 1980s -- Pan Am may be more vulnerable to an economic downturn than other, stronger carriers.

For the quarter that ended June 30, Pan Am reported a net loss of $49 million.