BOSTON, NOV. 8 -- Groupe Bull, the Paris-based computer manufacturer, said today it will slash its U.S. staff by 2,400 -- more than 21 percent of its domestic work force -- as part of an international restructuring.

The company said it plans to reduce its work force by 5,000 worldwide, or more than 10 percent of its current 47,000 total. Bull already laid off 2,000 workers during 1989 and 3,000 more so far this year.

Bull also projected it would lose about $511 million this year. In the first half of the year alone, it lost about $376 million.

The actions announced today are part of its effort "to confront the worldwide crisis facing the information systems industry," the company said. Growth in the industry has slowed in recent years from its previous clip of 30 percent or more a year.

Bull said the plan is aimed at helping the company turn a profit by 1992.

The company said it will lay off up to 1,000 employees in Massachusetts; 250 in Arizona, where it also plans to close a plant; 170 at the St. Joseph, Mich., plant of its Glenview, Ill.-based Zenith Data Systems subsidiary; and 350 in field locations across the United States.

In addition to the year-end layoffs, the company expects to eliminate 400 workers through voluntary severance and early retirements by Dec. 14, said Bonnie Kaplan, a spokeswoman for Groupe Bull's U.S. subsidiary, Bull HN Information Systems Inc. of Billerica, Mass.

Also, Groupe Bull plans to trim 100 of its 900 employees in Canada, Kaplan said.

Patrick Marks, a Bull spokesman in Paris, did not specify where additional U.S. layoffs would be made.

But the company said Groupe Bull's plant in Chandler, Ariz., which currently employs 85, will be closed as part of a consolidation that will eliminate seven of the company's 13 plants worldwide by 1992.