THE HOUSE on 22nd Street" -- which very appropriately sounds like the title of a spy novel about Washington's cloak-and-dagger world of international intrigue -- is for sale and may have a buyer.

The $500,000 townhouse at 1016 22nd Street NW, only a few blocks from the White House and the State Department off Washington Circle, belongs to former CIA- operative Edwin P. Wilson, who left the country three years ago. At that time his "merchant-of-death" dealings in global weapons peddling became the subject of a federal grand jury investigation here. A grand jury is investigating Wilson's activities.

Wilson, a swashbuckling John Wayne look-alike who began his clandestine CIA career as a $5-an-hour mechanic on the U-2 spy plane missions of the 1950s and the 1960s, became a multimillionaire. Former associates claim his land holdings in Virginia alone now rival that of the super-rich Mellon family.

The 22nd Street property, which looks like a private residence from the street, has been used by Wilson to house various "business" and "consulting" ventures since leaving the CIA in 1971.

The house has a lower-level closed garage which allows cars to whisk in and out via an electronic door-opener with minimum exposure to public view.

This appealed in 1978 to "Koreagate" figure Tongsun Park, when he called there on one of Wilson's associates who was developing a special security system for the late President Park Chung Hee's "Blue House" residence in Seoul.

Park talked about buying the house then, or trying to buy one of the others in that row.

Wilson and Park, both now expatriated to London, have become friends, according to those who know them both.

Several weeks ago, sources say, Japanese businessmen associated with Park in shipping and other ventures showed up to inspect the property on park's recommendation.

Wilson's wife, Barbara, still living here on their showplace Upperville farm and a part owner of the 22nd Street house, has not returned telephone calls about the Park group's interest in the prospective purchase.

House Speaker Thomas P. (Tip) O'Neill has told a close associate that he will serve one more term and retire to play golf and gin rummy.He has no intention, according to one source, of stying around as long as some of his predecessors, including Sam Rayburn, who died on the job at age 79, and John McCormack, who retired at 79 in 1971.

The Canal Co. in Georgetown is a place Sen. John Warner can't resist everytime he gets his hair cut at Jean Pierre's. He was a homebody even before he married Elizabeth Taylor and buys antique brass hardware and plumbing fixtures. Recently he bought a huge antique brass ladle too big to be anything but decorative . . . Warner's collecting is only one of the reasons his "Atoka Farm" in Middleburg is such a showplace. He ended up with the farm after his divorce from Cathy Mellon. The Associated Press's Bryan Brumley, attending a party at Atoka, was asked by his mother, Jane Ikard: Would you like to marry a Mellon?" Looking around him, Brumley replied: "No, but I wouldn't mind divorcing one."

First Passover and then the transit strike in New York has delayed the appearance of witnesses before the grand jury looking into cocaine-sniffing charges against White House Chief of Staff Hamilton Jordan. Some witnesses were rescheduled four and five times before testimony started last week . . . The White House won't confirm or deny, but Carter administration insiders are claiming that he had one very dramatic rendezvous at sea aboard a Sixth Fleet vessel during his supersecret negotiations with Iranian officials over the release of the hostages . . . Jordan, so invisible around the White House recently that even some of those working for him never saw enough of him to know if he was present or absent, is back to his one-hour late-afternoon tennis games on the South Lawn. His favorite partner is Carter-Mondale counsel Tim Smith, son of the late Merriman Smith, onetime dean of the White House Press corps . . .

There's a new Washington address for Hess and Eisenhardt, the Cincinnati company which manufactured all the Secret Service's armored cars, along with the bulletproof limousines used by Canada's Pierre Trudeau, the Vatican and Queen Elizabeth.

Heads of state and oil-rich sheiks now will deal with Hess and Eisenhardt's International division, operating out of Suite 300 at 2550 M St. NW. That 's the same suite where Global Research, Inc. -- a company into which both former attorney general John Mitchell and former president Richard M. Nixon reportedly have "input" -- recently opened up.

A spokesman for Hess and Eisenhardt denied last week that the two companies have any connection.

On May 1, President Carter is losing one of his closest and least-known confidants.

For the past 13 months, former Georgia Supreme Court judge William Gunter has praticed law in Washington and was summoned many an evening for a drink or dinner when the president wanted someone to listen and counsel him.

Now, after keeping one of the lowest profiles of any presidential adviser in years, Gunter is moving back to Atlanta and a practice "where I know every lawyer and judge in the state."

"It takes five or six years in Washington to get into the swing of things," he says, "and at my age (61) I don't have the time."