The folks who put out Fortune magazine are geniuses. In 1949, they predicted that computers would create a "second industrial revolution." In 1971, they forecast the rise of the VCR. In 1977, long before Prozac, they predicted the impact of mood-altering drugs. In 1980, they recognized that the Solidarity movement in Poland was "a truly epochal event -- an irreparable crack in the foundations of the communist order."

The folks who put out Fortune are idiots. In 1934, they dismissed fascism as "essentially a local issue." In 1939, they announced that it was "practically impossible for Roosevelt to be elected in 1940." In 1961, they reported that American Protestantism was fading away. In 1974, they raised alarms about the threat of "global cooling."

Obviously, the folks who put out Fortune have had their ups and downs over the past 75 years. But, as their fascinating new 75th-anniversary special issue reminds us, they publish the best business magazine in America.

Fortune was conceived by Henry Luce, the magazine genius who had created Time six years earlier and who would create Life six years later. Fortune was born at the worst possible time for a big, glossy business mag -- 1930, the very depths of the worst depression in American history.

A memo Luce wrote back then reveals how little he understood the financial situation: "We will not be over-optimistic. We will recognize that this business slump may last as long as an entire year."

Of course, the "slump" lasted longer than a decade, but Fortune managed to survive, partly because of Luce's deep pockets and partly because of its impressive roster of talent. Over the years, it employed soon-to-be-famous writers James Agee, Archibald MacLeish, Dwight Macdonald and John Kenneth Galbraith and soon-to-be-famous photographers Walker Evans, Margaret Bourke-White and W. Eugene Smith.

In 1934, Fortune sent Agee and Evans to Alabama to produce a story on the plight of impoverished sharecroppers. As it turned out, Agee's prose was far too poetic and personal to run in Fortune but the collaboration, published as the book "Let Us Now Praise Famous Men," became an American classic.

A couple of decades later, Fortune launched another American classic when staffer William H. Whyte turned his series on postwar corporate culture into a book called "The Organization Man."

In this anniversary issue, Fortune recalls those past triumphs but doesn't dwell on them. Instead, the nostalgic pieces share space with Fortune's usual array of excellent articles on contemporary topics. There's a balanced piece on Thomas Friedman, the controversial New York Times columnist and best-selling globalization guru, and his many vociferous critics.

Even better is a piece called "The Law of Unintended Consequences." It's a convincing analysis of how the 1980 Bayh-Dole Act, designed to enable universities to profit from the scientific discoveries of their researchers, has ended up fostering secrecy, greed and lawsuits while impeding the flow of medical knowledge.

"Universities have evolved from public trusts into something closer to venture capital firms," writes senior editor Clifton Leaf. "What used to be a scientific community of free and open debate now often seems like a litigious scrum of data-hoarding and suspicion."

For magazine buffs, though, the best piece in this terrific issue is Carol Loomis's "My 51 Years (and counting) at Fortune."

Now 76, Loomis is one of the little-known heroes of journalism. A dogged investigative reporter -- she read 50 years of annual reports for a recent article on Bethlehem Steel -- Loomis specializes in holding the Gucci-clad feet of America's CEOs to the fire. The titles of her greatest hits give you an idea of her bite: "The Madness of Executive Compensation," "AT&T Has No Clothes," "The $600 Million Cigarette Scam" and "Recipe for Jail," a prescient pre-Enron 1999 piece on fraudulent corporate accounting that was illustrated by a cover photo of ledger books being cooked in a big stewpot.

When Loomis arrived at Fortune in 1953 at age 24, her only experience in business journalism was editing an in-house magazine for Maytag dealers. But her biggest handicap was her sex.

"It was assumed throughout the Luce empire," she writes, "that men wrote and women, paid less of course, assisted them as reporters and fact-checkers."

Under this system -- which persisted until New York's attorney general sued Time Inc. for sexual discrimination in 1970 -- a male writer and his female researcher would travel together on reporting trips. One married writer earned a reputation as a lecher for hitting on every researcher who accompanied him.

"My response, when my turn came, was to slap him," Loomis writes. "Somehow he managed to get past that trauma and write a first-class story, whose title I will omit."

Despite Fortune's sexism, Loomis thrived, and by 1957 she was working on the famous Fortune 500 list, which was, she writes, "a crash course in accounting, a subject I liked immediately."

She caught on quickly. Soon she was poring through the small print in wills, annual reports, SEC filings and other eye-glazing documents, ferreting out the information that revealed book-cooking and other corporate shenanigans.

Among her targets was her employer. After Time Inc. merged with Warner Communications in 1989, Loomis wrote an expose of one of the new company's major stockholders -- "The Enrichment of John Malone." After Time Warner merged with America Online in 2000, Loomis wrote a piece predicting -- correctly -- that the new company's stock would be a dog.

In 2003, she followed up with a piece exposing how AOL had fabricated $400 million in bogus ad revenues. For that story, she tried to interview Time Warner CEO Dick Parsons. When Parsons sent back word that he'd talk only off the record, she told him she didn't work that way and wrote the story without him.

Loomis has guts and integrity, and ranks with Fortune's other great writers. She wrote this memoir with brio and wit. It's an inspiring piece that ought to be required reading in America's journalism schools.

Investigative reporter Carol Loomis, a Fortune staffer since 1953.