Three sisters: searching for a cure

Wednesday at 8 p.m. on HBO

This new documentary chronicles the race to save the life of Jenifer Estess, who was diagnosed with amyotrophic lateral sclerosis (Lou Gehrig's disease) in 1997. The fatal disorder has no cure or treatment, and Estess was told she had from two to five years to live.

Estess, a theater and film producer, teamed with her sisters Valerie and Meredith to create a nonprofit organizaton that has raised $18 million and brought together scientists from Johns Hopkins University, Columbia University, Harvard and the Salk Institute to work on a cure and treatment.

At the time of filming, Jenifer Estess was six years into ALS and paralyzed from the neck down.

Las Vegas Live

Sunday at 9 p.m. on Bravo

Forget casinos, showgirls and the strip. This special focuses on the entertainers who made Las Vegas the vacation destination it is today. The two-hour special starts with the headliners of yesteryear, such as Frank Sinatra and Dean Martin, and ends with a look at the mainstream acts that pack in the crowds today, from Celine Dion to Cirque de Soleil.

I Sit where i want:

the legacy of brown

v. the board of education

Monday at 9 p.m. on the N

This hour-long special for teenage viewers examines the relevance of the 1954 court decision that brought upheaval as it forced the desegregation of America's schools. The documentary tracks students at a magnet school in Buffalo who participated in a program to diversify their lunchroom and their lives. The teenagers were paired biracially and spent time in each other's homes.

The N, called Noggin during the day, is on some satellite and digital systems.

tv science classics weekend

Friday at 6 p.m. on Science

A weekend of classic TV science shows kicks off with a tribute to the very first one. Even if you're not old enough to remember "Watch Mr. Wizard" -- in real life, Donald Jeffrey Herbert -- you'll appreciate the simple wizardry of the man whose on-air experiments used milk bottles rather than test tubes.

A 24-hour marathon of "Watch Mr. Wizard" episodes begins on Friday at 6 p.m. Other classic science shows will be shown through Monday at 6 p.m., including "Connections," "Secret Life of Machines," "The Ascent of Man" and "The Twenty-First Century