-------------------AIDS DRUGS IN DEVELOPMENT ---------------------

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Anti-Virals

Drugs that directly attack HIV, the virus that causes AIDS

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DRUG NAME (Generic Name): L-721

MANUFACTURER:Ethigen (Los Angeles, Calif.)

INDICATION: ARC,persistent generalized lymphadenopathy (PGL)

DEVELOPMENT STATUS: IND approved Phase II

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DRUG NAME (Generic Name): Betaseron (interferon beta)

MANUFACTURER: Triton Biosciences (Shell Oil) (Alameda, Calif.)

INDICATION: AIDS, Kaposi's sarcoma, ARC

DEVELOPMENT STATUS: IND approved Phase I/II

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DRUG NAME (Generic name): Cytovene (ganciclovir)

MANUFACTURER: Syntex (Palo Alto, Calif.)

INDICATION: CMV

DEVELOPMENT STATUS: NDA Pending (Orphan Drug)

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DRUG NAME (Generic name): DDC (dideoxycytidine)

MANUFACTURER: Hoffmann-La Roche (Nutley, N.J.)

INDICATION: AIDS, ARC

DEVELOPMENT STATUS: IND approved Phase I/II

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DRUG NAME (Generic name): (dextran sulfate; UA001)

MANUFACTURER: Ueno Fine Chem. Industry (Osaka, Japan)

INDICATION: AIDS, ARC

DEVELOPMENT STATUS: IND approved Phase I

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DRUG NAME (Generic name): Foscarnet (trisodium phosphonoformate)

MANUFACTURER: Astra Clinical Research (Hopkinton, Mass.)

INDICATION: HIV infection, CMV retinitis

DEVELOPMENT STATUS: IND approved Phase I/II

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DRUG NAME (Generic name): HPA-23

MANUFACTURER: Rhone-Poulenc Sante (Monmouth Junction, N.J.)

INDICATION: HIV infection

DEVELOPMENT STATUS: IND approved Phase I

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DRUG NAME (Generic name): Ornidyl (eflornithine)

MANUFACTURER: Merrell Dow (Cincinnati, Ohio)

INDICATION: PCP

DEVELOPMENT STATUS: NDA pending (Orphan Drug)

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DRUG NAME (Generic name): Peptide T (octapeptide sequence)

MANUFACTURER: Peninsula Labs (Belmont, Calif.)

INDICATION: AIDS

DEVELOPMENT STATUS: IND approved Phase I

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DRUG NAME (Generic name): Reticlose (nucleophosphoprotein)

MANUFACTURER: Advcanced Viral Research (Miami, Fla.)

INDICATION: AIDS, ARC

DEVELOPMENT STATUS: IND submitted

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DRUG NAME (Generic name): Retrovir (zidovudine; AZT)

MANUFACTURER: Burroughs Wellcome (Research Triangle Park, N.C.)

INDICATION: AIDS, advanced ARC

DEVELOPMENT STATUS: NDA approved

INDICATION: pediatric AIDS, Kaposi's sarcoma, asymptomatic HIV infection, less severe HIV, neurological involvement, in combination with other therapies

DEVELOPMENT STATUS: IND approved Phase I/II

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DRUG NAME (Generic name): Rifabutin (ansamycin LM 427)

MANUFACTURER: Adria Labs (Dublin, Ohio)

INDICATION: ARC

DEVELOPMENT STATUS: IND approved Phase II

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DRUG NAME (Generic name): (trimetrexate)

MANUFACTURER: Warner-Lambert (Morris Plains, N.J.)

INDICATION: PCP

DEVELOPMENT STATUS: IND approved Phase III

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DRUG NAME (Generic name): Virazole (ribavirin)

MANUFACTURER: Viratek/ICN (Costa Mesa, Calif.)

INDICATION: AIDS, Kaposi's sarcoma, ARC

DEVELOPMENT STATUS: IND approved Phase II/III

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DRUG NAME (Generic name): Wellferon (alpha interferon)

MANUFACTURER: Burroughs Wellcome (Research Triangle Park, N.C.)

INDICATION: Kaposi's sarcoma, HIV, in combination with Retrovir

DEVELOPMENT STATUS: IND approved Phase I

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DRUG NAME (Generic name): Zovirax (acyclovir)

MANUFACTURER: Burroughs Wellcome (Research Triangle Park, N.C.)

INDICATION: AIDS, ARC, in combination with Retrovir

DEVELOPMENT STATUS: IND approved Phase I

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Immuno-Modulators

Drugs that enhance the body's ability to fight invaders.

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DRUG NAME (Generic name): ABPP (bropirimine)

MANUFACTURER: Upjohn (Kalamazoo, Mich.)

INDICATION: Advanced AIDS, Kaposi's sarcoma

DEVELOPMENT STATUS: IND approved Phase II/III

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DRUG NAME (Generic name): AS-101

MANUFACTURER: Scientific Testing (National Patent Development, Bar Ilan University, Israel) (New York, N.Y.)

INDICATION: AIDS

DEVELOPMENT STATUS: IND approved

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DRUG NAME (Generic name): Ampligen (mismatched RNA)

MANUFACTURER: DuPont (Wilmington, Del.), HEM Research (Rockville, Md.)

INDICATION: ARC, PGL

DEVELOPMENT STATUS: IND approved Phase III

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DRUG NAME (Generic name): (anti-human alpha interferon antibody)

MANUFACTURER: Advanced Biotheraph Concepts (Rockville, Md.)

INDICATION: AIDS, ARC

DEVELOPMENT STATUS: IND approved Phase I

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DRUG NAME (Generic name): Carrisyn (acemannan)

MANUFACTURER: Carrington Labs (Irving, Tex.)

INDICATION: ARC

DEVELOPMENT STATUS: IND submitted

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DRUG NAME (Generic name): Colony Stimulating Factor (GM-CSF)

MANUFACTURER: Sandoz (East Hanover, N.J.) Genetics Institute (Cambridge, Mass.)

INDICATION: AIDS, Kaposi's sacrcoma, ARC, HIV

DEVELOPMENT STATUS: IND approved Phase I

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DRUG NAME (Generic name): CL246,738

MANUFACTURER: American Cyanamid (Pearl River, N.Y.)

INDICATION: AIDS

DEVELOPMENT STATUS: IND approved Phase I/II

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DRUG NAME (Generic name): (gamma interferon)

MANUFACTURER: Genentech (South San Francisco, Calif.)

INDICATION: ARC, in combination with TNF (tumor necrosis factor)

DEVELOPMENT STATUS: IND approved clincal trials

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DRUG NAME (Generic name): IMREG-1

MANUFACTURER: Imreg (New Orleans, La.)

INDICATION: AIDS, Kaposi's sarcoma, ARC, PGL

DEVELOPMENT STATUS: IND approved Phase III

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DRUG NAME (Generic name): IMREG-2

MANUFACTURER: Imreg (New Orleans, La.)

INDICATION: AIDS, Kaposi's sarcoma, ARC, PGL

DEVELOPMENT STATUS: IND approved Phase II

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DRUG NAME (Generic name): Imuthiol (diethly dithio carbamate)

MANUFACTURER: Merieux Institute (Miami, Fla.)

INDICATION: AIDS, ARC

DEVELOPMENT STATUS: IND approved Phase II/III

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DRUG NAME (Generic name): IL-2 (interluekin-2)

MANUFACTURER: Cetus (Emeryville, Calif.)

INDICATION: AIDS, Kaposi's sacrcoma

DEVELOPMENT STATUS: IND approved Phase II

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DRUG NAME (Generic name): IL-2 (interleukin-2)

MANUFACTURER: Hoffmann-La Roche (Nutley, N.J.), Immunex (Seattle,

Wash.)

INDICATION: Kaposi's sarcoma

DEVELOPMENT STATUS: IND approved Phase III

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DRUG NAME (Generic name): INTRON-A (interferon alpha)

MANUFACTURER: Schering-Plough (Madison, N.J.)

INDICATION: Kaposi's sarcoma

DEVELOPMENT STATUS: NDA filed

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DRUG NAME (Generic name): Isoprinosine (inosine pranobex)

MANUFACTURER: Newport Pharmaceuticals (Newport Beach, Calif.)

INDICATION: ARC, PGL, HIV seropositive asymptomatic patients

DEVELOPMENT STATUS: IND approved Phase III

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DRUG NAME (Generic name): (methionine-enkephalin)

MANUFACTURER: TNI Pharmaceuticals (Chicago, Ill.)

INDICATION: AIDS, ARC

DEVELOPMENT STATUS: Investigator's IND approved Phase I/II

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DRUG NAME (Generic name): MTP-PE (muramyl-tripeptide)

MANUFACTURER: Ciba-Geigy (Summit, N.J.)

INDICATION: Kaposi's sarcoma

DEVELOPMENT STATUS: IND approved Phase I

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DRUG NAME (Generic name): Thymopetin (TP-5) (thymic compound)

MANUFACTURER: Ortho Pharmaceuticals (Raritan, N.J.)

INDICATION: HIV infection

DEVELOPMENT STATUS: IND approved Phase I/II

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DRUG NAME (Generic name): Roferon-A (interferon alpha)

MANUFACTURER: Hoffmann-La Roche (Nutley, N.J.)

INDICATION: Kaposi's sarcoma

DEVELOPMENT STATUS: NDA filed

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DRUG NAME (Generic name): (recombinant erythropoietin)

MANUFACTURER: Ortho Pharmaceuticals (Raritan, NJ)

INDICATION: severe anemia associated with AIDS and AZT therapy

DEVELOPMENT STATUS: IND approved Phase II

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DRUG NAME (Generic name): Trexan (naltrexone)

MANUFACTURER: DuPont (Wilmington, Del.)

INDICATION: AIDS, ARC

DEVELOPMENT STATUS: early Phase II

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DRUG NAME (Generic name): TNF (tumor necrosis factor)

MANUFACTURER: Genentech (South San Francisco, Calif.)

INDICATION: ARC, in combination with gamma interferon

DEVELOPMENT STATUS: IND approved clinical trials

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Anti-Infectives

Drugs that fight opportunistic infections

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DRUG NAME (Generic name): Pentam 300 (pentamidine isethionate, IV

dosage)

MANUFACTURER: LyphoMed (Rosemont, Ill.)

INDICATION: PCP

DEVELOPMENT STATUS: NDA approved

DRUG NAME (Generic name): Pentam 300 aerosol dosage

MANUFACTURER: LyphoMed (Rosemont, Ill.)

INDICATION: PCP prophylaxis, PCP treatment

DEVELOPMENT STATUS: IND approved Phase III

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DRUG NAME (Generic name): (fluconazole)

MANUFACTURER: Pfizer (New York, N.Y.)

INDICATION: cryptococcal meningitis, candidiasis

DEVELOPMENT STATUS: IND approved Phase III

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SOURCE: Pharmaceutical Manufacturers Association