Spiro T. Agnew, who is moving to southern California, is trying to sell his Arnold, Md., house for between $150,000 and $180,000.

The former Vice President quietly put the two-story, four-bedroom colonial home on the selling block last weekend with a small ad in the Annapolis Evening Capitol telling of a "one of a kind" house.

There was no mention that it belonged to the Agnews, who have lived in the house since June, 1974. "Based on past experience, I don't think it makes one bit of difference that it's his house, as far as selling it goes," said realtor Colin F. McGowan.

Agnew announced last fall that he intended to move to Palm Springs, Calif., where his friend Frank Sinatra lives. He is having a home built there that is supposed to be ready in April. He said he will keep his Croton, Md., international consulting business, and his condominium in Ocean City.

Agnew bought the house, located on a wooded 1.25 acre lot in the Indian Hills subdivision near Annapolis, for between $100,000 and $150,000, McGowan said. The house, which has a brick and aluminum siding, has four bedrooms, four baths, a family room, a recreation room, a wet bar and a custom-built wine rack.

McGowan said he had "been talking for some time" with Agnew about selling the house. McGowan built the house and sold it to Agnew after the former Vice President pleaded no contest to a tax evasion charges and resigned from office.