Two Falls Church residents were killed Thursday when the cars in which they were riding collided on Great Falls Street in McLean, Fairfax County police reported yesterday.

The victims were Carolyne L. Pumphrey, 53, of 2905 Cherry St., and Harlan E. Freeman, 50, of 1916 Hillside Dr. Mrs. Pumphrey's husband, Ernest Z., the driver of their car is listed in serious condition at Arlington Hospital with a fractured right knee, right leg and nose.

According to police, Freeman's car, headed west in the 2300 block of Great Falls, ran off the road onto the shoulder. When Freeman pulled back onto the road, police said, the car went over the center line and struck the Pumphrey's car, which was eastbound.

In another fatal accident, one man was killed and six others, including a Virginia state trooper, were injured late Thursday when the policeman's car slammed into a vehicle it was pursuing in a high-speed chase in Loudoun County.

According to witnesses, the vehicle being pursued had attempted to elude the police car about 10:50 p.m. by turning out its lights and slowing down on Rte. 15, south of Leesburg. They said the police car, coming over a small rise in the road rammed into the unlighted car from behind, killing one of the four occupants.

The fatal victim was identified as Victor E. Colmes of Marshall. Trooper K. L. Hyden was treated for a fractured right arm and forehead cut at Loudoun Memorial Hospital and released. Carlos White of Marshall, one of the three passengers in the pursued car, was listed in critical condition at Fairfax Hospital. The other two passengers, Daniel Dorsey of Ashville and Herman King of Delaplane, were listed in satisfactory condition of Loudoun Hospital.

Loudoun Deputy Sheriff A. M. Keyes, who was struck on the elbow by the sideview mirror of a passing car while at the accident scene, was treated at the hospital and released.