Navy Rear Adm. Frank Benjamin Guest Jr., 57, a combat veteran of World War II and the Korean conflict, died of cancer Tuesday at the Navy Regional Medical Center in Philadelphia.

At the time of his health, he headed the Military Sea Lift Command, Atlantic, Headquartered in Bayonne, N. J.

Adm. Guest was on-the-scene commander for the International Naval Review held for the Bicentennial in New York last July 4.

From 1975 through December, 1976, he also had been commandant of the 3d Naval District, comprising New York, Northern New Jersey and Connecticut.

Although he and his family maintained a permanent home in Potomac, he and his wife, Joan Kuhn Guest, and two of their eight children, Stephen and Joan, were living at the Brooklyn Navy Yard at the time of his death.

Born in Washington, Adm. Guest graduated in 1943 from the Georgetown University School of Foreign Service. He was commissioned in the Naval Reserve that year and placed on active duty.

From 1943 to 1946, he served with the pacific Fleet Amphibious Force aboard the attack transport U.S.S. Neville, seeing action in the Marshall and Mariana Island campaigns.

Adm. Guest left active service after the war and returned here, where he was in private business until 1950, when he was recalled to active duty.

He again served aboard an attack transport, the U.S.S. Calvart, and was wounded in Korea.

From the end of 1951 until the beginning of 1954, Adm. Guest was on duty wit the Bureau of Naval Personnel in Washington. He later commanded the destroyers U.S.S. Timmerman, U.S.S. Bronson and U.S.S. Hunt, and led Destroyer Squadron 34.

In 1968, he was appointed special assistant for reserve affairs under the assistant secretary of the Navy for manpower and reserve affairs, then special assistant to the commander for Navy recruiting and deputy chief for naval reserve.

Also surviving are his six other children, Sister Marcia, OSM, of Omaha, Neb., Navy Lt. Frank B. III, based in Norfolk,Richard and James, of Washington, Robert, of New York City, and Ellen, of Boulder, Colo; a sister, Marcia Clopton, of Chevy Chase, and two grandchildren.

The family suggests that expressions of sympathy may be in the form of contributions to the American Cancer Society.