Daniel D. McDonald, 49, director of tribal resources development for the Bureau of Indian Affairs, died Saturday at Suburban Hospital in Bethesda after a breif illness.

Appointed to the position in 1974, he was one of four program directors in the bureau. His office was responsible for assisting Indians through the development of business enterprises, credit and financing, and manpower and placement programs. It also provided technical assistance to tribes in road construction and development.

A Nez Perce/Flathead Indian, Mr. McDonald was bon on the Flathead Reservation in Montana.

After serving with the Marine Corps in World Was II, he earned a degree from the University of Montana and later took graduate work at George Washington University.

He started with the Bureau of Indian Affairs in about 1957 as a relocation assistant on the Ft. Belknap Reservation at Harlem, Mont.

From 1963 until 1970, Mr. McDonald was a bureau industrial development specialist on the Navajo Reservation.

He played a key role in the establishment of the General Dynamics plant at Fort Defiance, Ariz., the establishment of the first supermarket on the reservation, and the Window Rock, Ariz.

He also was instrumental in the expansion of the Fairchild Semiconductor Division at Shiprock, N.M., which became the largest single employer of Indians in this country.

Mr. McDonald came to Washington in 1970 as director of intergovernmental relations with the National Council on Indian Opportunity.

He is survived by his wife, Gloria Gardipe McDonald, and four children, Richard, Mark, John and LIssa, all of the home in Rockville; his mother, Lydia McDonald, of the Flathead Reservation and three brothers and three sisters.