Frank W. Clarke, 67, founder and president of a Northern Virginia real estate firm bearing his name, died Tuesday at Fairfax Hospital after a short illness.

Born in Dinwiddie County, Va., Mr. Clarke was educated in Alexandria schools. He worked on the Arlington Journal until the outbreak of World War II. During the war years, he served in the 8th Air Force as a radio operator, completing 35 missions.

Mr. Clarke founded the firm of Chauncey and Clarke Real Estate and Insurance. In 1949, the name was changed to F. W. Clarke Co., and in 1960, it became Clarke and Sampson. Mr. Clarke was president of the firm until his retirement in 1968.

He was a past president of the Northern Virginia Board of Realtors and a member of the board of directors of the Alexandria Chamber of Commerce. He was also a member of the Belle Haven County Club, the Arlington Lions Club, the board of appraisals of the First Federal Savings and Loan Association, and the Andrew Jackson Masonic Lodge of Alexandria.

Mr. Clarke is survived by his wife, the former Helen Cannon, of the home in Alexandria, and two sisters, Mrs. A. John Scariot and Mrs. Leslie Phelps, and two brothers, Robert I. and Everette R., all of Alexandria.