Louise B. Simons, 65, wife of retired Rear Adm. Manley H. Simons Jr. and an accomplished water color artist, died of cancer Saturday at Bethesda Naval Hospital.

Mrs. Simons was born in Jacksonville, Fla., and studied architecture at Auburn University in 1930.

Between her marriage in 1931 and 1959, Mrs. Simons lived in nearly a dozen cities in the United States, spending four years in Arlington in the late 1940s and early 1950s. It was there that she first began painting seriously.

She had lived in Bethesda since 1959.

Mrs. Simons was a student of several distinguished artists, including Eliot Hara of Washington. She won first prize for water colors in the 1968 Art Club of Washington members' show.

Her paintings have been exhibited at the Smithsonian Institution, the Newport, R.I., Art Museum, and the Down East Gallery in Glen Echo. Mrs. Simons also had individual shows at the Norfolk, Va., Museum of Art and the Gallery Coffee House in Georgetown.

She was a member of the American Art League and of the Miniature Painters, Sculptors and Gravers Society of Washington, of which she was a past president.

She was also a member of St. Dunstan's Episcopal Church in Summer, Md.

Surviving are her husband, of the home in Bethesda, a daughter Gale Burwell of Bethesda, and two grandchildren.

The family requests that expressions of sympathy be made in the form of contributions to the Montgomery County chapter of the American Cancer Society.