Eda Elizabeth Jose Wire, 75, active for many years in philanthropic organizations, died Wednesday at her summer home in Rehoboth Beach after a long illness.

She was the widow of Preston E. Wire, who built the Wire Building on Vermont Avenue and developed Wire Properties, Inc. in the mid-1940s. He died in 1952.

Mrs. Wire remained active in the company and was chairman of the board at the time of her death.

Born in Washington, she had lived for many years on Loughboro Road NW and frequently opened her home to the public for fund-raising benefits. She had resided in Overlook, Md., for the last three years.

Mrs. Wire was one of the original members of Women's Auxiliary of the D.C. Society for Cripple Children. She was active in the work of the Florence Crittenton Home.

She was a member of the Congressional County Club, the Rehoboth Beach County Club and Metropolitan Memorial United Methodist Church.

She is survived by three children, Preston E. Wire Jr, of Bethesda, Jean W. Tubbs, of Rehoboth Beach, and Myrl W. Mulligan, of Davie, Fla; three sisters, Florence M. Somerville, Della B. Harvey and Kathryn J. Proctor, all of the Washington area, seven grandchildren and two great-grandchildren.

The family suggests that expressions of sympathy be in the form of contributions to the D.C. Society for Crippled Children.