Rebecca Serilla Wolfsohn, 75, active in the Jewish community here, died Tuesday at Suburban Hospital in Bethesda after a stroke.

She was the widow of Joel David Wolfsohn, assistant secretary of the Interior in the Truman administration and a Washington lawyer. He died in 1961.

Born near Odessa, Russia, Mrs. Wolfsohn came to this country at the age of two with her family, settling in Chicago. She was a librarian with the city school system there before coming to Washington with her husband in 1934.

Mrs. Wolfsohn, who lived in Chevy Chase, was a member of Beth El Congregation and its Sisterhood. She was active in the women's auxiliary of the Hebrew Home of Greater Washington and Hadassah.

She was past president of the women's division of the American Society fo Technion, a school of higher education in Haifa, and a member of the women's auxiliary of Brandeis University.

She is survived by a daughter, Jacqueline Aronfy, of New Carrollton, Md.; a brother, Fred J. Simon, of Bowie, and two grandchildren.

The family suggests that expressions of sympathy may be in the form of contributions to the Joel David Wolfsohn Memorial Fund at Beth El Congregation or the Joel David Wolfsohn Scholarship Fund at Brandeis University.