Dolores A. Blake, 54, wife of U.S. Ambassador to Iceland James J. Blake, died Wednesday at Andrews Air Forces Base.

Mrs. Blake had been flown to Washington from Iceland on an emergency medical flight. She died of a heart ailment as the flight arrived at Andrews.

Mrs. Blake had served with her husband in Brussels, Calcutta, Tripoli and Reykjavik, Iceland.

She was born in New York City and graduated in 1944, magna cum laude, from Queens College with a degree in economics. She worked for a year after graduation for the Sheffield Co. in New York as an economist.

She then married, and for one year lived in Peru, Neb., before coming to Washington with her husband. They had maintained a home here since then.

Mrs. Blake was a member of the American Foreign Service Wives Association and St. Ann's Roman Catholic Church in Washington.

In addition to her husband, she is survived by a daughter, Kathleen, of Chicago, David, of Washington, and Robert, of Ann Arbor, Mich; her parents, Mr. and Mrs. David L. Quaid, of Floral Park, N.Y.; two sisters. Dorotht Erb, of Floral Park, and Geraldine Ryan, of Katonah, N.Y., and two brothers, David Quaid, of Mount Kisco, N.Y., and Donald Quaid, of Paramus, N.J.