William T.Knox, 60, Director of the National Technical Information Service of the Department of Commerce, died of cancer Thursday at Georgetown University Hospital.

He became director of the information service in 1971. It stores films and printed material on nearly every scientific advance, analysis, invention or discovery made with federal funds. "Nobody has any idea how much of a resource we are," Mr. Knox said in an interview last year. "We have it all, organized and available on computer printout to anybody who wants it. Nothing is ever out of print!!!"

Mr! Knox, who held 15 patents and was the author of numerous articles for scientific publications, entered government service in 1964.

Named to the staff of the Office of Science and Technology in the White House Executive Office, he was primarily responsible for stimulating development of more effective scientific and technical information systems in this country.

From 1966 to 1971, he was a corporate vice president of McGraw-Hill Inc.

Born in Social Circle, Ga., Mr! Knox was a graduate of Mercer University in Macon, Ga., and earned a master's degree in science from Virginia Polytechnic Institute,

From 1938 to 1964, he worked in research and then management and planning with the Esso Research and Engineering Co. in Linden, N.J. He helped create Esso's first scientific information system.

Mr! Knox had been a member of the Cosmos Club, the computer science and engineering board of the National Academy of Science and technology and on communications of the U.S. Chamber of Commerce.

He belonged to the American Institute of Chemical Engineers, the American Institute of Chemists, the American Association for the Advancement of Science, the Associastion of Computing Machinery and the American Society for Information Sciences.

He is survived by his wife, Celia Deese Knox, of the home in Chevy Chase; two sons, William T. IV, of Basking Ridgge, N,J., and Robert F., of San Francisco; a daughter, Mrs. Guy Fisher, of Cherry Hill, N.; his mother, Mrs! William T. Knox, and a sister, Mrs. David Daley, both of Saint Simons Island, Ga.; another sister, Mrs. John Mattox, of Mclean, and five grandchildren.

The family suggests that in the form of contributions to the American Cancer Society