Prince George's County police arrested six people and confiscated an estimated $150,000 worth of the hallucenogenic drug PCP during a raid on an Oxon Hill home Wednesday night, a police spokesman reported yesterday.

Police, armed with a search warrant, discovered a laboratory where the drug allegedly was manufactured in a separate building at the rear of a homes at 1215 Van Buren Dr.

From the laboratory, police recovered both the finished PCP - the common name of the drug phencycledine - and materials used to manufacture the drug, according to the police spokesman.

The Wednesday night search culminated a two month investigation by officers of the Prince George's County police department, a special task force of the U.S. Drug Enforcement Agency, and officers of the Charles County Sheriff's Department.

The DEA's involment is part of a task force effort designed to find laboratories in the Washington area that are manufacturing CP. The hallucenogenic drug, known on the street as Angel Dust or Killer Weed, has been growing rapidly in popularity among local teen-agers in recent years.

David G. Canaday, special agent in charge of the DEA's Washington office said that the PCP task force has been operating since Jan. 1 and has discoved nine PCP labs.

'We've put special emphasis on looking for these labs because we know how much PCP has grown in popularity," Canaday said.

Canaday said about 20 agents have been working with local police in searching for the PCP labs. He said there might be further arrests in connection with Wednesday's raid.

Arrested and charged with manufacturing PCP, possession with intent to distribute PCP and maintaining a common nuisance were the occupants of of the Oxon Hill house, Carl D. MacDonald, 22 and his wife, Terri M. MacDonald, 22.

Also arrested, and charged with manufacturing PCP were, Raul H. Guevera, 32, and Nancy G. Litton, 22 - both of Hume, Va. - and William H. Dale Jr. of 3200 Orleans Ave., Forestville, Regina A. Mavilia, 23, was charged with possession of marijuana.

The MacDonalds and Mavilia were released on personal recognizance, police said. Guevera is being held in lieu of $6,000 bond, they said, and Litton and Dale are being held on $2,000 bond.