Samuel S. Levin, 80, an official of the U.S. Patent Office for 43 years, died of cancer Friday at his home in Rockville.

Mr. Levin was born and raised in Baltimore. He earned a bachelor's degree in chemistry at the Carnegie Institute of Technology in Pittsburgh in 1920. After working as a chemist in Indiana for two years, he joined the Patent Office in 1922 as an examiner.

In 1952, he became a member of the Board of Patent Interferences. This is the agency that decides disputes about patents at the Patent Office level. He remained in the board until his retirement in 1965.

Mr. Levin received the Meritorious Service Award from the Commerce Department in 1959 for outstanding service in the Patent Office, which is part of Commerce.

Mr. Levin served in the Army chemical corps during World War I. He earned a law degree from George Washington University in 1926. He lectured and wrote about patent law for professional journals.

He was a member of the American Legion and of the Federal Lodge No. 1 of the Masons.

Survivors include his wife, the former Reba Smelkinson, whom he marrie din 1926, of the home in Rockville; two sons, Neal T., of South Orange, N.J., and Dr. Ira W., of Rockville; and five grandchildren