Diane Miller Cooley, 46, a resident of Reston for the past 14 months, died Wednesday at George Washington University Hospital. She has been surffering from scleroderma, a skin disorder.

Mrs. Cooley moved to the Washington area when her husband, David W. Cooley, became president of the American Chamber of Commerce Executives. They previously had lived in Dallas, Memphis and other cities.

Mrs. Cooley was bron in Florence, S.C. She grew up there and in Arden, N.C. She graduated from the old Women's College of the University of North Carolina in Greensboro and was a teaching graduate there.

In addition to her husband, of the home in Reston, she is survived by four children, Ann, of Hampton, Va., John, a student at Virginia Polytechnic Institute and University in Blacksburg, Va., and Phillip and Mathew, of the home; and three brothers, Roderick W. Miller, of Hendersonville, N.C., Harry S. Miller Jr., of Salisbury, N.C., and Gerald Miller, of Hinckley, N.C.

The family suggests that expressions of sympathy be in the form of contributions to the Diane Cooley Memorial Scleroderma Research Fund, Sam Hunt, trustee, co South-Fund, Sam Hunt, trustee, c/o Southern Bank and Trust Co., P.O. Box 1329, Greenville, S.C., 29602.