Mary Elizabeth Crandall Reed, 35, who helped raise some of the animals at the National Zoo, where her husband, Dr. Theodore H. Reed is director, died Thursday at the National Institutes of Health. She suffered from cancer.

She had brought up two of the zoo's famous white tiger cubs, Rewaiti and famous white tiger cubs, Rewait and Moni, as well as leopards and at least a half-dozen bear cubs at the Reed's former home in Bethesda. They recently moved into Washington.

Mrs. Reed had maintained an interest in animals since her marriage in 1945 to Dr. Reed, a veterinarian. They met while they were students at Kansas State University, where she graduated with a degree in industrial journalism.

They went to the Kansas City zoo on their honeymoon. Later they lived in Oregon, where Dr. Reed was an assistant sale veterinarian. Mrs. Reed often accompanied her husband as he traveled about the state inspecting animals.

He was veterinarian of the Portland zoo when he was hired by the National zoo in 1955, and they came to Washington. She was particulary interested in the zoo's services to the public and recently, while in a wheelchair, offered ideas on how to make it easier for the handicapped to get around the zoo.

Mrs. Reed was born in LeRoy, Kan. After coming here, she was active in St. Columba's Episcopal Church.

In addition to her husband, she is survived by a son, Mark, of San Antonio, Tex; a daughter, Maryalyce of New Zealand; her mother, Mrs. L.E.Crandall, and a sister, Doris Trostle, both of LeRoy, and another sister, Louise Crandall, of Lansing, Mich.

The family suggests that expressions of sympathy may be in the form of contributions to St. Columba's Church or the American Cancer Society.