Wilma Brogan MacPherson, 74, who was active in Northern Virginia Republican organizations in the 1940s and 1950s, died of kidney failure Friday in a Boca Raton, Fla., hospital.

She served as president of the Virginia Council of Republican Women in the early 1950s, and was a charter member of the Arlington Republican Women's Council. She served two terms as president of the Arlington Republican Women's Club in the 1940s, and was named to the Arlington County Republican Committee in 1942.

Mrs. MacPherson also did volunteer work for the blind, helping to establish Lions Club eye banks and had headed an Arlington County Mothers March Against Birth Defects.

She was the wife of Colin C. MacPherson, who was Arlington County treasurer for 20 years before retiring in 1971.

Mrs. MacPherson taught school in Virginia for 14 years, the last four years in Washington-Lee High School, before retiring in 1939. She had belonged to the Citizens Committee for School Improvement.

Mrs. MacPherson was a native of Franklin County, Va., and moved to the Washington area in the mid-1930s. She was a graduate of Radford College.

In addition to her husband, of the home in Arlington and Pompano Beach, she is survived by a son, Robert, and a sister, Minnie B. Smith, both of Arlington; two other sisters, Elsie B. Evans, of Winston-Salem, N.C., and Geneva B. Shea, of Vero Beach, Fla.; two brothers, Fred C. Brogan, of Glen Burnie, and Charles H. Brogan, of Baltimore, and two grandchildren. CAPTION: Picture, WILMA B. MacPHERSON