Lois Hall Henderson, 80, a retired clerk at the Interstate Commerce Commission who was active in patriotic organizations, died Wednesday at Alexandria Hospital. She had emphysema.

Mrs. Henderson was born in Mooresville, N.C. She moved to the Washington are from Asheville, N.C., during World War II. She was a Red Cross Grey Lady during the war and worked at Walter Reed Hospital.

She also went to work for the federal government and remained with it until her retirement from the ICC in 1966. She was a resident of Washington until her death.

She was a regent of the Constitution chapter of the Daughters of the American Revolution, a national activities chairman for the annual DAR constitutional conventions, a president of the Robert E. Lee chapter of the United Daughters of the Confederacy, and Virginia state head of the Children of the Confederacy.

For many years she was a committee chairwoman for the annual garden party given for the Salvation Army in this area.

Her husband, Louis Henderson, died in the 1960s.

Survivors include a son, William Hall Trotter, of Alexandria, by a previous marriage to the late Millard F. Trotter, a sister, Beatrice Hall McLauchlin, of Charlotte, N.C., and four grandchildren.