Hypatia (Pat) W. Holm, 73, who was active in the Girl Scouts and community and cultural affairs in Northern Virginia, died Wednesday at Circle Terrace Hospital in Alexandria following a stroke. She had cancer.

Mrs. Holm was a Girl Scout leader for 27 years, with particular expertise in pioneer camping. She moved to the Washington area from Texas in 1946, and continued her scouting activities in Arlington, where she also was active in the PTA and as a volunteer with the American Field Service Program.

In 1963, she and her family moved to Annandale, where she and her husband particpiated in square-dancing groups. Mrs. Holm also taught folk and square dancing to young people's organizations in this area.

Mrs. Holm helped organize the Red Fox Garden Club in Annandale and presented many of its programs. She was active in the American Association of University Women and led many of the association's cultural and historical tours.

She was born in Ellinwood, Kan., and earned a bachelor's degree from Kansas State University in 1927.

She and her husband, Lionel (Pete) Holm, celebrated their 50th wedding anniversary last year.

Besides her husband, of the home in Annandale, survivors include two sons, the Rev. Duane S., of Cincinnati, and Dr. Wayne S., of Chinle, Ariz.; two daughters, Janice Lloyd, of Princeton, Ill., and Patricia Lister, of Oxon Hill; a brother, M. Waldo Wilcox, of Kirkland, Wash., and nine grandchildren.

The family suggests that expressions of sympathy be in the form of contributions to the American Cancer Society. CAPTION: Picture, HYPATIA W. HOLM