Jonathan Sobeloff, 44, a professor at the Georgetown University Law Center since 1966, died of cancer Friday at his home in Bethesda.

He taught federal income taxation, taxation of corporations and shareholders and estate and gift taxation. He was a faculty adviser to the center's legal publication, The Tax Lawyer.

Mr. Sobeloff was the author of several tax books and of articles on federal tax procedures, tax accounting and taxation of employe compensation and corporate stock offerings. He was a consulting editor to "Tax Barometer."

In a statement issued Friday, David J. McCarthy, dean of the law center, called Mr. Sobeloff a dedicated and effective teacher who had made "important and lasting contributions" to his profession.

Mr. Sobeloff was born in New York City. He was a graduate of the University of Michigan, where he was elected to Phi Beta Kappa, and of Harvard Law School, where he was on the board of editors of the Harvard Law Review.

He practiced law in Detroit from 1958 until 1962, when he came to Washington as an attorney-adviser in the Treasury Department's office of tax legislative counsel.

He then had a private law practice in Washington for two years before joining the Georgetown Law Center faculty. He was a consultant to the Office of the Treasury Secretary until his death.

Mr. Sobeloff was a member of the Michigan, D.C., and U.S. Supreme Court bars. He was active in the American Law Institute, the Internarional Fiscal Association, the National Tax Association - Tax Institute of America, the Federal and American Bar associations and the Association of American Law Schools.

He is survived by his wife, Barbara, and three daughters, Judith, Deborah and susan, all of the home, and his parents, Isidore and Edith Sobeloff, of Los Angeles.

The family suggests that expressions of sympathy be in the form of contributions to the Montgomery County chapter of the American Cancer Society. CAPTION: Picture, JONATHAN SOBELOFF