Frank Leslie Campbell, 80, an entomologist and retired executive secretary of the division of biology and agriculture at the National Academy of Sciences-National Research Council, died of cancer Friday at George Washington University Hospital.

He had served in that position from 1953 until retiring in 1964. He then returned to research in insect morphology. He was a pioneer in research on insect structure, growth and development and the toxicity of insecticides.

Dr. Campbell was one of the first scientists to use a radioactive isotope as a tracer in insect toxicology. The use of DDT in Switzerland was brought to the attention of American entomologists by Dr. Campbell in 1942.

He was born in Philadelphia, attended Haverford College in Pennsylvania and graduated with a degree in chemical engineering from the University of Pennsylvania. He earned a master's degree from Rutgers University and a doctorate at Harvard University.

After teaching at New York University, Dr. Campbell joined the Bureau of Entomology at the Agriculture Department in Washington in 1927.

Nine years later, he joined the faculty of Ohio State University, where he remained until 1942, when he came back to Washington as a consultant on agricultural chemicals essential to food production in the Office for Agricultural War Relations.

In the latter part of World War II, he was back at Ohio State working with its Research Foundation on war-related research.

After the war, he served in Washington for five years as editor of the Scientific Monthly, a publication of the American Association for the Advancement of Science. He wrote a column, "The Brownstone Tower," which referred to his office in the Smithsonian's "Castle."

Dr. Campbell was with the Central Intelligence Agency from 1948 to 1953.

After his 1964 retirement, he was a visiting professor at the Zoological Institute of the University of Vienna in Austria and at the University of New England in Australia. From 1969 to 1974, he did research at Virginia Polytechnic Institute in Blacksburg.

Dr. Campbell was a former president of the Entomological Society of Washington and the Washington Academy of Sciences. He was a founder of the Insecticide Society of Washington.

He belonged to the Association of Economic Entomologists, the Entomological Society of America, the National Pest Control Association and the Cosmos Club.

His first wife, E. Mildred Boyd, died in 1946.

He is survived by his second wife, Ina Lee, of the home in Washington; a son, Drew B., of Inglewood, Calif.; a daughter, Lucile Cooper, of Baton Rouge, La., and seven grandchildren. CAPTION: Picture, FRANK LESLIE CAMPBELL, 1964 Photo