Frank A. Briglia, 53, an official of the Central Intelligence Arm Agency, and his wife, Naomi Belle Briglia, 47, were killed Friday in an auto accident on Interstate 81 near Christiansburg, Va. They lived in Vienna, Va.

The accident occurred when a tractor-trailer, traveling in the opposite direction, crossed the 15-foot median strip and collided with their car, according to a spokesman for the Montgomery County, Va., sheriff's office. The driver of the truck was treated at a local hospital and released. Investigation of the accident is continuing.

Mr. Briglia had been deputy director of the agency's office of research and development for the past three years. Before joining the CIA in 1966, he was president of American Scientific Corp., an Alexandria research and development company, and worked for Melpar Inc.

He served aboard aircraft carriers with the Navy during World War II.

Mr. Briglia was a native of Atlantic City, N.J., and earned a degree in electrical engineering at the University of Tennessee at Knoxville.

He was working for the Western Electric Co. in North Carolina when he met his future wife, also a company employee. They were married in Burlington, N.C., in 1954.

They came here about a year later, and Mrs. Briglia became active in the Lady of Good Counsel Catholic Church in Vienna. She belonged to the Republican Women's Club of Virginia and the Westbrier Civic Association. She also worked for several years as a real estate agent in Northern Virginia.

Mrs. Briglia was a native of Snow Hill, Md., and attended Elon College in Elon, N.C.

Surviving are four sons, Frank Jr., Anthony A., Steven D., and Michael D., all of the home in Vienna.

Mrs. Briglia is also survived by his mother, Maria Cortese Briglia, and three sisters, Louise Menardy, Nita B. Williams, and Marie Ferry, all of Atlantic City, N.J., and two brothers, Joseph, of Primos, Pa., and Arnold, of Florence, Ala.

Mrs. Briglia also is survived by her mother, Mrs. Dewey A. Brown, a brother, Dewey A. Brown Jr., and a sister, Rebecca DeVette, all of Graham, N.C., and four other sisters, Linda Riddle, of Annandale, Betty Plomondon, of Denver, Mary Roberts, of Sacramento, Calif., and Charlotte Baker, of Spring, Tex.

The family suggests that expressions of sympathy be in the form of contributions to the Heart Fund. 130:Picture 1, NAOMI BELLE BRIGLIA; Picture 2, FRANK A. BRIGLIA