Leila Bram, 52, director of the mathematics program at the Office of Naval Research, died of cancer Sept. 7 at Northern Virginia Doctors Hospital.

After two years as an Office of Naval Research postdoctoral fellow at the University of Chicago, Dr. Bram joined the office here in 1953. She remained with the office until her death except for a period from 1955 to 1959.

Dr. Bram was active in the political and technical problems faced by mathematical research and played a key role in the progress made in channeling mathematical research into practice. She was an adviser on studies related to mathematics and mathematicians.

She was born in Drexel Hill, Pa. She graduated from Bryn Mawr College and earned master's and doctor's degrees from the University of Pennsylvania.

Dr. Bram, who lived in Arlington, was a member of the American Mathematical Society, the Society for Industrial and Applied Mathematics, the Mathematical Association of America and the American Association for the Advancement of Science.

She is survived by four children, Marion Bram of Boulder, Colo., Alan Bram of Berkeley, Calif., Richard Bram of Palo Alto, Calif., and Charles Bram of Boston; her mother, Katherine Dragonette of Arlington, and two sisters, Jane Dragonette of Arlington, and Jessica Gordon of New York City.