Santina Irene Bellino, 71, a Catholic lay worker who also was active in civic and charitable organizations for many years, died of cancer Thursday at Georgetown University Hospital.

Mrs. Bellino was the wife of Carmine Bellino, a former FBI agent and Senate investigator, whom she married in 1936.

A native of Elizabeth, N.J., Mrs. Bellino taught grammar school there after graduating from the State Teacher's College in Trenton, N.J.

She and her husband, who also was a special consultant to President John F. Kennedy, moved to the Washington area in 1939, when Mr. Bellino was transferred to FBI headquarters here.

Mrs. Bellino, who lived in Bethesda, was active in the Catholic Daughters of America and the National and Archdiocesan Councils of Catholic Women. She was president of the National Council in the early 1970s.

She served as president of the board of directors of the Association of Ladies of Charity of the U.S. in 1966 and 1967. She was a former treasurer of the Christ Child Society and a member of the Children of Mary at Stone Ridge School in Bethesda.

Mrs. Bellino also was a member of the Third Order of Dominicans, and a charter member of the Altare Dei unit of the Ladies Sodality at St Jane Frances de Chantal Catholic Church in Bethesda.

She was a volunteer for the United Way, the American Cancer Society and community bloodmobile campaigns.

Besides her husband, of Bethesda, survivors include three sons, Dr. Francis L., of Buffalo, Robert C., of Belmont, Calif., and Joseph C., of Mount Rainier; four daughters. Mary Catherine Van Deven of Arnold, Mo, Mary Joan Mastrangelo of Clarksburg, Mass., Mary Sandra Foster of Newark, Del., and Mary Joyce Benson of Browns Summit, N.C.; two sisters, Angela Novello of Washington, and Josephine Bevins, of Miami Beach, Fla; a brother, Paul Novello of Rahway, N.J., and 20 grandchildren.