Catherine S. Manno, 69, a retired government statistician who had been active in political organizations, died of cancer Sunday at the Washington Home Hospice.

Mrs. Manno worked as a sampling statistician for the Agriculture Department for about 20 years before spending 1957 to 1958 as a United Nations statistical adviser to the government of Thailand.

She then worked for the Census Bureau from 1964 until retiring in 1971.

Since leaving the government she had worked for and served on the boards of the Women's International League for Peace and Freedom and the Capital Area United Nations Association.

Mrs. Manno was born in Louisville, Ky., and reared in Dayton, Ohio. She was a graduate of Antioch College in Yellow Springs, Ohio, and earned a doctoral degree in international relations at American University.

She was a resident of the District of Columbia.

Survivors include her husband, Joseph, of Washington; two brothers, August Senf of Dayton, and Henry Senf of California; and two sisters, Mary Louise Senf of Dayton, and Rita Senf of New York City.

The family suggests that expressions of sympathy be in the form of contributions to the Washington Home Hospice, the Capital Area United Nations Association, or the Women's International League for Peace and Freedom.