Alice Sipes Doerr, 68, a retired international relations officer for the Department of State and a former Washington resident, died of cancer Tuesday at St. Mary's Hospital in Leonardtown, Md.

Mrs. Doerr was born and reared in Baltimore. In 1949, she joined the State Department and subsequently worked for the old Bureau of Near Eastern, African and South Asian Affairs the old Psychological Strategy Board and the old Refugee Relief Program, here and in Vienna, Austria.

From 1956 to 1958, she was secretary to the chief of the economic section at the U.S. embassy in Paraguay. She then became personnel officer for the Central Treaty Organization in Turkey and worked for the Office of the Coordinator of Cuban Affairs in Miami, and for the U.S. embassy in Finland before returning here in 1966.

A former Washington resident, Mrs. Doerr lived in Piney Point, Md., and in Jupiter, Fla., in recent years.

Her first husband, Norman Sikes, an area lumberman, died in 1955.

Survivors include her husband, John Doerr, a retired Foreign Service officer, of Piney Point and Jupiter; two sons by her first marriage, William Sipes of Panama and Donald N. Sipes of Westminster, Md.; two sisters, Helena Duffen of Tucson, Ariz., and Nellie Lantz of New Windsor, Md., seven grandchildren and five great-grandchildren.

The family suggests that expressions of sympathy be in the form of contributions to the American Cancer Society.