Mae Dreifus, 74, who was active in civic and senior citizens organizations in Northern Virginia, died June 14 in a hospital in Berkeley Springs, W.Va., after a stroke.

A resident of Alexandria since 1944, Mrs. Dreifus was in West Virginia attending a "no-smoking" retreat at the time she was stricken.

She had been a member of the Alexandria Commission on Aging since 1975. She had done volunteer work with senior citizens in Alexandria since 1970 and belonged to the American Association of Retired Persons.

Mrs. Dreifus had served as chief judge at several precinct polling places during elections and had been a member of the Alexandria Electoral Board since 1972.

She was a member of the Beth El Hebrew Congregation in Alexandria, and of its Sisterhood. She also was a member of Hadassah.

Mrs. Dreifus was a native of New Jersey and a graduate of New York University. She worked as a department store buyer in New York and Missouri before coming here in 1944. She worked for Lansburgh's Department Store in Washington in the late 1940s.

She was the widow of Dr. Carl T. Dreifus, an Alexandria dentist, who died in 1970.

Her survivors include two sons, Robert, of Alexandria, and Jordan, of California; a sister, Bessie Tensor of Boston, and two Grandchildren.

The family suggests that expressions of sympathy be in the form of contributions to the Beth El Hebrew Congregation, or to the Andrus Foundation Research Studies in Gerontology, 215 Long Beach Blvd., Long Beach, Calif., 90801.