Dr. George Louis Weller Jr., 73, who practiced internal medicine in Washington for 46 years and who was staff medical director for the D.C. fire and police departments from 1937 to 1961, died of cardiac arrest Sunday at his home in Washington.

Dr. Weller was born in Baltimore and earned bachelor's and medical degrees from Johns Hopkins University. He was an intern at Peter Bent Brigham Hospital in Boston, Mass., and then moved to Washington, where he opened his office in 1934.

In addition to his private practice and his work with the police and fire departments, Dr. Weller was a physician on call to the White House from 1937 to 1961. He also was an adjunct professor at George Washington University medical school.

During World War II, he served in the Army and was stationed at Walter Reed Army Hospital.

Dr. Weller, who continued to practice until his death, was a fellow of the Royal Society of Hygiene and of the American Institute of Chemists. He also was a member of the board of the New York Academy of Sciences. He received the "Physician's Recognition Award" from the American Medical Association.

He published papers in numerous professional journals.

Dr. Weller was a member of the University, Cosmos, Army & Navy and Congressional Country Clubs.

Survivors include his wife, the former Jan A. Cook, of Washington; a daughter, Cynthia Weller Koch, of Greewich, Conn., and four grandchildren. dAnother daughter, Jane Weller Haynes, died in 1973.

The family suggest that expression of sympathy be in the form of contributions to the How to Survive Book Fund for further publication of Dr. Weller's work, c/o Welko, 575 Madison Ave., New York City, 10022.